Clinical Trials Show Higher Spatial Resolution, Less Noise, Fewer Artifacts, And Color Capabilities in Patients’ Images
GRENOBLE, France – Sept. 3, 2020 – A novel X-ray photon-counting detector module (PCDM) developed by CEA-Leti and integrated in an X-ray scanner prototype from Siemens Healthineers has shown in clinical trials the potential to revolutionize computed-tomography (CT) scanning by potentially increasing spatial resolution, reducing X-ray exposure to patients, improving image quality by lowering image noise and artifacts, and by distinguishing multiple contrast agents.
Early in their technology collaboration, Siemens Healthineers asked CEA-Leti to design, integrate, manufacture, and test a new generation of PCDM that will become mature enough to be integrated into an X-ray CT scanner prototype.
X-ray PCDMs based on cadmium telluride (CdTe) allow simultaneous acquisition of high-spatial-resolution and multi-energy images. Higher spatial resolution improves image quality by using a small-pixel size detector, while image noise can obscure features, and artifacts can mimic them. Multi-energy provides color images, compared to grey-level images of conventional detectors, and allows a precise determination of the atomic number of any chemical elements present in the body.
“The successful early collaboration with CEA-Leti allowed Siemens Healthineers to prototype what the med- tech company sees as the future of detector modules for whole-body CT,” said Jean-Michel Casagrande, the project manager for medical X-ray imaging at CEA-Leti.
X-ray CT scanners use computer-processed combinations of many X-ray measurements taken from different angles to produce cross-sectional images of scanned objects. Current X-ray CT scanners produce images with energy-integrating detectors (EIDs), which are based on indirect conversion technology: X-ray photons are first converted into visible light using scintillator material, then visible photons produce electronic signals using a photodiode. PCDMs, on the other hand, directly convert X-ray photons into electronic signals with a higher conversion yield.
Precise Determination of the Atomic Number
In addition, EIDs register the total energy deposited in a pixel during a fixed period of time without discriminating between low- and high-energy photons. This produces a monochrome X-ray image that shows the density of the body’s organs. PCDMs count each photon, which improves the contrast-to-noise ratio of the image, and the energy classification of the detected photons can be used to produce a color image that allows a precise determination of the atomic number of any chemical elements and a distinction of multiple contrast agents present in the body.
Finally, the detector module’s very high spatial resolution generates clearer images of very-fine structures, such as small airways in the lungs, trabeculae in bones, and thin wires in coronary stents than current scanner technology.
“The idea of Siemens Healthineers to integrate PCDMs in the future generation of X-ray CT scanners was new and no available technology existed when CEA-Leti began working on this,” said Loick Verger, the industrial-partnership manager for X-ray imaging at CEA-Leti. “The technical challenge – low noise at a very high counting rate, two energy classifications, and sufficient maturity to be integrated in an X-ray CT scanner – was tremendous.”
Verger explained that CEA-Leti used its simulation tools to design the geometry of the detector, chose a semiconductor based on CdTe, designed the electronic readout circuit, and then was able to propose a reliable CdTe electronic assembly technology.
Mayo Clinic Evaluation
“Researchers at the Mayo Clinic in the U.S. have evaluated Siemens Healthineers’ photon-counting detector system’s performance in phantoms, cadavers, animals, and humans. Images of more than 300 patients produced with this technology consistently demonstrated that the theoretical benefits of this type of detector technology yield a number of important clinical benefits,” said Cynthia McCollough, professor of Medical Physics and Biomedical Engineering at the Mayo Clinic.
“Publications by our research team have shown improved spatial resolution, decreased radiation or iodine contrast dose requirements, and decreased levels of image noise and artifacts,” McCollough said. “Additionally, the ability to simultaneously acquire multiple 150-micron-resolution datasets, each representing a different energy spectrum, is anticipated to lead to new clinical applications.”
Recent publications by the Mayo team highlight some of these anticipated benefits for patients. For example, a 2020 paper in Investigative Radiology by Rajendran et al demonstrated the ability to reduce radiation dose by up to 85 percent for high spatial-resolution imaging of the inner ear and surrounding bone.
“It is extremely rewarding to see the exquisite images that can be made using the technologies of the detector module that we developed,” Verger said. “Seeing for ourselves the clinical benefits of all our R&D efforts motivates our entire team to continue the development of cutting-edge technologies for improving healthcare.”
About CEA-Leti (France)
Leti, a technology research institute at CEA, is a global leader in miniaturization technologies enabling smart, energy-efficient and secure solutions for industry. Founded in 1967, CEA-Leti pioneers micro-& nanotechnologies, tailoring differentiating applicative solutions for global companies, SMEs and startups. CEA-Leti tackles critical challenges in healthcare, energy and digital migration. From sensors to data processing and computing solutions, CEA-Leti’s multidisciplinary teams deliver solid expertise, leveraging world-class pre-industrialization facilities. With a staff of more than 1,900, a portfolio of 3,100 patents, 10,000 sq. meters of cleanroom space and a clear IP policy, the institute is based in Grenoble, France, and has offices in Silicon Valley and Tokyo. CEA-Leti has launched 65 startups and is a member of the Carnot Institutes network. Follow us on www.leti-cea.com and @CEA_Leti.
CEA has a key role in transferring scientific knowledge and innovation from research to industry. This high-level technological research is carried out in particular in electronic and integrated systems, from microscale to nanoscale. It has a wide range of industrial applications in the fields of transport, health, safety and telecommunications, contributing to the creation of high-quality and competitive products.
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